FORWARDED EMAIL TO TRUMP, KUSHNER, GATES, MITSOTAKIS
CAN T GET ONTO TWITTER, X
.png)
LEGAL INFORMATION
NOT SPAM
Dear Tedros Adhanom Ghebreyesus, Director General of WHO,
When Sky News asked you if WHO will regret its hantavirus plan to disembark passengers from the MV Hondius and fly them back to their various countries because the passengers could spread the virus around the world, you said that based on your assessment, "this is not going to happen".
https://news.sky.com/video/sky-news-asks-dr-tedros-if-who-will-regret-hantavirus-plan-13542160
Could you, please, send me a copy of your assessment explaining how your plan to fly the passengers to a dozen countries is not going to lead to the hantavirus circulating wider than the cruise ship’s passengers and perhaps becoming a global epidemic?
You and WHO s intransparent actions are, you must realize, fuelling fears that WHO is once more engaged in creating pandemics out of thin air to direct vast amounts of money to pharmaceutical companies as part of future global forced hantavirus vaccination campaigns as it was accused of doing in 2010 in a report by the Council of Europe.
A HANTAVIRUS PANDEMIC FOR THE PROFIT OF PHARMACEUTICAL COMPANIES?
In 2010, a report by the Council of Europe, Paul Flynn MP criticised WHO s role in the swine flu pandemic calling it an "unjustified waste of public money" and "one of the greatest medicine scandals of the century". It argued that the WHO exaggerated the severity of the virus, causing worldwide panic and leading governments to spend billions on vaccines and antivirals.Findings: The report accused pharmaceutical companies of influencing WHO decisions to declare a "pandemic."
National governments, WHO, and EU agencies had all been guilty of actions that led to a “waste of large sums of public money, and unjustified scares and fears about the health risks faced by the European public,” said the report.
The report identified what it called “grave shortcomings” in the transparency of decision-making about the outbreak, generating concerns about the influence of the pharmaceutical industry on decisions taken. Plummeting confidence in such advice could prove “disastrous” in the case of a severe future pandemic, it warns.
https://pace.coe.int/en/news/2937/pace-health-committee-denounces-unjustified-scare-of-swine-flu-waste-of-public-money
https://assembly.coe.int/nw/xml/XRef/Xref-XML2HTML-en.asp?fileid=17889&lang=en
https://www.bbc.com/news/10235558
https://www.thebureauinvestigates.com/stories/2010-06-07/who-swine-flu-advisors-had-links-to-drug-companies
https://www.bmj.com/content/340/bmj.c3033
What is new is that sixteen years after this damning report, what is new today, in 2026 is the number of people who believe you and WHO are trying to start a new pandemic using the hantavirus for the profit of pharmaceutical companies.
Katherine Wallace wrote in Statnews that to view the hantavirus as a pharmaceutical scheme in which WHO is involved is the new normal.
"What worries me most is not that misinformation exists. It’s that we’ve started treating this environment as normal."
"That audience is enormous. And it’s growing," she added.
https://www.statnews.com/2026/05/08/hantavirus-outbreak-misinformation-spreads-faster-than-virus/
The enormous number of people who now, in 2026, believe WHO is part of a criminal scheme has significant legal implications for you, and your associates, including Pedros Sanchez, because of the definitive proof it is in the form of prosecutor probes in Geece E 17 449 and D 15 218 among other proofs.
https://www.dropbox.com/scl/fi/frci8gkqajfy8jfwj6cs9/2017-Grk-prosecutor-probes-convict-Kushner-of-covid-treason-Iran.pdf?rlkey=tz6jztrrgfjorigb8p1vzwfj1&st=60q3gz5g&dl=0
https://www.dropbox.com/scl/fi/xmvdermyzjhnje9z1hbkq/GRKProsecutorProbesConvictSoros-GatesOfMurderAttemptsOnReporter.pdf?rlkey=n4gz1whwa9vj8iktkg7ymxn6v&st=obi9i3b4&dl=0
https://drive.google.com/file/d/1qDt2oc6Ag_3V7wRCrT2xohF1MtsXOyC5/view?usp=sharing
And the number sure to keep growing as people cannot make sense of your decisions.
A HANTAVIRUS PANDEMIC FOR THE PROFIT OF MODERNA AND ITS INVESTORS?
The markets clearly are already betting that you and WHO will declare a global epidemic and a rollout of hantavirus vaccines because Moderna s shares have soared about 30% since the hantavirus outbreak.
The fact the markets believe your plan will lead to a huge outbreak of hantavirus, justify billions in tax payer funded contracts? for the hantavirus vaccines and so bring a return to the enormous amounts of money now being invested into Moderna shares brings me to the problems raised by an investigation into WHO s handling of the swine flu in 2009.
When we talk about a global pandemic declared by WHO, we are talking about a very profitable business as discussed already in the 2010 Council of Europe report
Did the profits of pandemic play a role in your decision to violate the IHR to disperse the cruise ship passengers?
VIOLATIONS OF THE IHR 2005 TO DISEMBARK PASSENGERS
Under Article 27 Authority (Affected Conveyances) of International Health Regulations 2005, a ship can be quarantined by the "competent authority" and prevented from docking and the passengers prevented from disembarking turning the ship into a quarantine zone precisely in order to prevent the international spread of a disease.
Fernando Clavijo, the president of the Canary Islands’ regional administration, announced that he would not authorize the ship to dock to stop the hantavirus from spreading.
However, he was blocked by you and the Prime Minister Pedro Sánchez who sanctioned or instigated the Director General of the Merchant Marine to sign an administrative resolution invoking Article 299 of the Ports Law, which overturned Clavijo’s veto and mandated the ship’s entry. The Hondius entered Granadilla six hours later, and the operation to disperse the passengers around the world continued.
Based on the principles of international law, the International Health Regulations (IHR 2005), specifically Article 27 ("Affected Conveyances"), generally take precedence over domestic port laws when a ship carries a significant public health risk, such as a deadly disease.
The IHR is a legally binding international treaty aimed at preventing the spread of disease.
As of 2026, the IHR has Supremacy in Public Health Emergencies. Under IHR Article 27, if a ship is deemed "affected" (e.g., has a deadly disease on board), the "competent authority" (port health authority) has broad powers, including disinfecting, decontaminating, or ordering isolation.Preventing Spread:
The overarching goal is to prevent the international spread of disease.
If local port law conflicts with the immediate need for quarantine to prevent a "serious public health risk," the health protocols (IHR) will prevail.
While IHR Article 28 generally protects a ship's right to enter a port, this is not absolute. States may refuse free pratique permission to enter/operate if they have evidence of a public health risk.
But you and WHO were so anxious it seems to disperse the passengers around the world that you overrode and violated the spirit and the letter of IHR 2005.
MISINFORMATION ON TRANSMISSION PATHS TO SPREAD FEAR?
The science showing a “low-probability transmission” is being buried also by WHO and a false narrative is rapidly amplifying the notion that virus is on its way to becoming an international emergency, thereby justifying WHO in declaring the hantavirus a global emergency, and imposing lockdowns as well as coercive mass vaccination s possibly with the a vaccines with a 98% adverse event rate given under emergency authorization like the covid jabs.
Is it any wonder that US media like Zerohedge are already accusing WHO of exaggerating the threat of the Hantavirus for financial gain as in 2010.
From Zerohedge
The bottom line? Hantavirus is all over the world and it's not a threat to the vast majority of people. The artificial media panic and the opportunism of the WHO may be an effort to test the waters for another fraudulent pandemic scare, but the majority of the propaganda seems to be aimed at restoring the WHO's reputation and saving it from financial ruin.
https://www.zerohedge.com/political/media-spreads-hantavirus-hysteria-attempt-save-disgraced-who
On the one hand, Swiss virologists who have sequenced the genome say the disease poses little risk to the public, because the virus spreads only through close contact, such as kissing or sharing food or drinks or bodily fluids.
“On 5 May 2026, the Swiss National Reference Center for Emerging Viral Infections (Geneva University Hospitals) confirmed a case of Andes strain in a Swiss resident who had travelled on the MV Hondius cruise ship. The virus was sequenced from blood samples jointly by the Institute of Medical Virology (University of Zurich) and the Swiss National Reference Center for Emerging Viral Infections (Geneva University Hospitals) using Illumina technology (MiSeq instrument). The consensus sequence was generated with a minimum coverage of 5 reads.
The complete ANDV/Switzerland/Hu-3337/2026 consensus sequence for each of the 3 segments can be found here:”
https://virological.org/t/complete-sequence-of-orthohantavirus-andesense-virus-swiss-resident-2026/1023
Swiss virologist Isabelle Eckerle from Geneva University Hospitals said there was no danger that the hantavirus would become a pandemic.
https://www.tagesanzeiger.ch/hantavirus-keine-pandemie-gefahr-908433735825
The Andes strain can be transmitted from person to person, but only in a rare and random cases with contact with infected rodents, Eckerle told Swiss TV.
On the other hand, WHO is tracking dozens of international flight contacts who shared cabin space with the deceased suggesting that the virus is airborne.
On the one hand, the virus is so deadly that you personally have to go with Pedro Sanchez to Tenerife to oversee the disembarkation and repatriation.
On the other hand, the virus is not deadly enough to warrant a quarantine on the ship.
Media like the widely read The Telegraph are now talking freely about hantavirus as an airborne, respiratory virus and as contagious as covid without pushback from WHO and governments.
From media
"If all caught the virus from patient zero, then the reproduction rate – the number of people each person infects – is nine. This is as high as the Covid-19 Omicron variant, although the confinement of the ship will have driven it much higher than would be expected in the wider environment.
But it means that Andes strain may transmit to people more easily than first thought, and anyone who crossed paths with those travelling back from the MV Hondius could be at risk,"
writes Sarah Knaption, a science editor, in a major UK newspaper, The Telegraph,thereby, confusing, intentionally or unintentionally, the different paths of transmission.
https://www.telegraph.co.uk/news/2026/05/11/the-crucial-date-when-we-will-know-if-hantavirus-has-spread/
"But the long incubation period of the virus means that it is impossible to know whether passengers who left the ship early on April 24 have passed on the disease.
Dr Steven Quay has calculated that all generation-two cases – those involving people who developed symptoms after contact with “patient zero”, Leo Schilperoord, 70 – took an average of 22 days to become ill.
The US physician-scientist estimates that generation-three cases – involving anyone who contracts the infection from the holidaymakers – should start showing up around May 19, if the same incubation period of approximately three weeks holds true."
https://www.yahoo.com/news/articles/crucial-date-know-hantavirus-spreading-174837776.html
On the one hand, the ECDC has said that rodents in Europe are not a natural virus for the Andes strain.
"In addition, the natural rodent reservoir for the virus is not present in Europe, making sustained spread in the community unlikely."
https://www.ecdc.europa.eu/en/infectious-disease-topics/hantavirus-infection/surveillance-and-updates/questions-answers-outbreak
On the other hand, Greek alt deputy health minister Erini Agapidaki is telling people to watch out for rats, suggesting they are carrying the Andes strain in Greece.
And how can you explain why the various countries to which passengers were repatriated use such radically different approaches to containing the disease? Which is right? Which is wrong?
The passengers are being kept in very different kinds of quarantine and isolation from loose, self monitoring to a 45 day isolation in a special quarantine unit with negative pressure in Greece to isolation at home 42 days in the UK.
This brings us to the question of how accurate the tests are and whether a fake epidemic is not being generated by false positives as happened during Ebola?
If the virus starts spreading, also by false positives or negatives, then are you not responsible at WHO for not keeping all the people on the ship guaranteeing a standard supervision knowing that the diagnostic tools have a record of being inaccurate?
And poison can also be used to simulate a virus outbreak.
THE HANTAVIRUS AS A US BIOWEAPON
A VACCINE CAUSING 98% ADVERSE EVENTS
The next problem is the involvement of US army bioweapons researchers given the record of the US army biowar units using defensive research as a cover for overt operations.
Moderna's (MRNA) stock rose significantly in early May 2026, gaining over 16% in five days, following news of a hantavirus outbreak linked to a cruise ship and the company's subsequent research into a vaccine.
Moderna began research on a hantavirus vaccine in 2023 and works in collaboration with the U.S. Army's Infectious Disease Medical Research Institute. Moderna is also working with the Vaccine Innovation Center at a South Korean medical school, Korea University College of Medicine (VIC-K).
Although hantavirus represents a limited commercial opportunity due to its low incidence,the markets invested big money clearly in the hope of for long-term revenue, expecting a mass vaccination campaign, it seems.
Investors have treated Moderna as a "must-own" stock during emerging infectious disease scares, similar to its role in the COVID-19 pandemic, because they are expecting mass vaccinations like covid ordered by WHO.
A study published on the hantavirus vaccine in 2023 in The Journal of Infectious Diseases on Safety and Immunogenicity of an Andes Virus DNA Vaccine by Needle-Free Injection: A Randomized, Controlled Phase 1 Study found a 98% of the people had an adverse event
https://pmc.ncbi.nlm.nih.gov/articles/PMC10786244/
The Journal of Infectious Diseases
J Infect Dis. 2023 Jun 28;229(1):30–38. doi: 10.1093/infdis/jiad235
Safety and Immunogenicity of an Andes Virus DNA Vaccine by Needle-Free Injection: A Randomized, Controlled Phase 1 Study
Grant C Paulsen 1,2,✉, Robert Frenck Jr 3,4, Kay M Tomashek 5, Rodolfo M Alarcon 6, Elizabeth Hensel 7, Ashley Lowe 8, Rebecca L Brocato 9, Steve A Kwilas 10, Matthew D Josleyn 11, Jay W Hooper 12,✉,1,3
PMCID: PMC10786244 PMID: 37380156
Abstract
Background
Andes virus (ANDV), a rodent-borne hantavirus, causes hantavirus pulmonary syndrome (HPS). The safety and immunogenicity of a novel ANDV DNA vaccine was evaluated.
Methods
Phase 1, double-blind, dose-escalation trial randomly assigned 48 healthy adults to placebo or ANDV DNA vaccine delivered via needle-free jet injection. Cohorts 1 and 2 received 2 mg of DNA or placebo in a 3-dose (days 1, 29, 169) or 4-dose (days 1, 29, 57, 169) schedule, respectively. Cohorts 3 and 4 received 4 mg of DNA or placebo in the 3-dose and 4-dose schedule, respectively. Subjects were monitored for safety and neutralizing antibodies by pseudovirion neutralization assay (PsVNA50) and plaque reduction neutralization test (PRNT50).
Results
While 98% and 65% of subjects had at least 1 local or systemic solicited adverse event (AE), respectively, most AEs were mild or moderate; no related serious AEs were detected. Cohorts 2, 3, and 4 had higher seroconversion rates than cohort 1 and seropositivity of at least 80% by day 197, sustained through day 337. PsVNA50 geometric mean titers were highest for cohort 4 on and after day 197.
...
Pathogenic orthohantaviruses are single-stranded RNA viruses that are members of the Hantaviridae family, order Bunyavirales, and can be found worldwide [1, 2]. The primary severe disease manifestations in humans are likely due to inflammation and endothelial cell disruption with increased vascular permeability, resulting in hemorrhagic fever with renal syndrome (HFRS) or hantavirus pulmonary syndrome (HPS) [3]. HPS is caused by region-specific hantavirus strains, predominantly the Andes virus (ANDV) strains in South America [4–6] and Sin Nombre virus in North America [7].
Key exclusions were receipt of a hantavirus vaccine (HTNV, PUUV); known exposure to ANDV or plans to travel to an ANDV endemic area through 6 months after last vaccination; history of severe reactions to vaccines or vaccine products or a severe allergic reaction; current acute illness or unstable chronic medical condition; history of an autoimmune, immunosuppressive, or immunodeficient condition; history of type 1 or 2 diabetes or any chronic neurologic disorder; receipt of any live vaccine within 28 days or inactivated vaccine (except influenza) within 14 days of study vaccination; and receipt of any experimental agent, blood product, or immunoglobulin within 3 months of the first study vaccination.
..
Solicited local and systemic AEs were common with 47 out of 48 (98%) subjects reporting at least 1 local AE and 31 (65%) reporting at least 1 systemic AE (Table 2 and Table 3). The most common local AEs were injection-site erythema (90%), induration (90%), tenderness (81%), and pain (67%). A higher proportion of vaccine recipients (70%, 28/40; 95% CI, 53%–83%) reported having at least 1 solicited systemic AE than placebo recipients (38%, 3/8; 95% CI, 9%–76%). The most prevalent systemic symptom was headache (52%), followed by fatigue (48%), and malaise (38%). Mild fever was reported in 3 vaccine recipients (7.5%, 3/40) in the 7 days after vaccination. The majority of all solicited AEs were mild (25%, 12/48) or moderate (58%, 28/48) severity. Six (15%) study vaccine recipients (4 from cohort 1 and 2, and 2 from cohort 3 and 4) experienced a total of 6 related grade 3 symptoms including headache (1), erythema (3), induration (1), and ecchymosis (1). All grade 3 symptoms were improved or resolved after 1 day.
Clinical Trials Registration. NCT03682107.
To clarify
The US Army already tested an Andes-strain hantavirus DNA shot—the SAME strain behind the cruise ship outbreak and 98% of the subjects suffered adverse events.
US ARMY PATENTS FOR HANTAVIRUS AND THE LAB ORIGINS OF COVID
In this context, the fact that the US army has had a patent on the hantavirus since 1997 raises big questions about whether the hantavirus outbreak has a link to a US army virus.
The U.S. Army Medical Research Institute of Infectious Diseases (USAMRIID) at Fort Detrick has studied hantaviruses for nearly 40 years, including developing antibody reagents for research.
You may know WHO has been accused of hiding from the global public the fact that covid came from a US lab and was engineered also by the US army.
This is now a fact.
David Morens has been indicted for hiding the fact that covid was from a lab.
https://www.justice.gov/opa/pr/former-senior-niaid-official-indicted-concealing-federal-records-during-covid-19-pandemic-0
Morens served as a senior adviser to Anthony Fauci from 2006 to 2022 at the US National Institutes of Health’s (NIH’s) allergy and infectious diseases institute.
Federal prosecutors claim that Morens used private email accounts for government business and deleted records and coordinated with co-conspirators to hide communications related to the origin of the Covid-19 virus in a lab and high-risk coronavirus research that the NIH was funding. Those co-conspirators include EcoHealth Alliance’s president Peter Daszak.
There have been calls for Fauci to be indicted for his role in secretly funding gain of function research on covid.
https://www.bmj.com/content/385/bmj.q1231
When the US army also funded hantavirus research for 40 years, people understandly get suspicions about its origins in the light of covid.
There is a research article in Antiviral Research on the Hantavirus by Jan P Clement which openly says that people thought the hantavirus came out a lab when it first emerged in 1993.
10.1016/S0166-3542(02)00205-X
Abstract
When hantaviruses hit the headlines with the advent in May 1993 of a new disease in the USA, and later in the New World from Canada to south Argentina, called “hantavirus pulmonary syndrome” (HPS), speculations in the lay press rose from the very beginning around the possibilities of a biological warfare (BW) weapon. Indeed, the responsible agent of HPS, hantavirus, was almost unknown at that moment in the New World, was airborne, seemed to target preferentially young adults, and induced a devastating cardio-pulmonary collapse with a high case-fatality rate (50%), often within hours. It quickly became clear, however, that the same scourge had been known for many years in the Old World under different and mostly milder presentations. With the rapidly increasing knowledge about hantaviruses, it also became clear that they lack many of the potentials of an “ideal” BW weapon, as will be explained in this paper.
Keywords
Hantavirus (HTV); Hantavirus pulmonary syndrome (HPS); Hemorrhagic fever with renal syndrome (HFRS); Nephropathia epidemica (NE); Rodent-borne infection; Biological warfare (BW); Vaccines
Date: January 2003
Pages: 121-127
Volume: Volume 57, Issues 1–2
Part of special issue
Viral Bioterrorism and Biodefence
Edited by E. De Clercq and E.R. Kern
...........
The number of patents for the hantavirus is eye opening.
HANTAVIRUS PATENTS
US5614193A — Hantavirus Vaccine
United States Army / Department of the Army
https://patents.google.com/patent/US5614193A/en
The patent (US5614193A) was filed in 1994 and granted on March 25, 1997.
It describes a vaccine using an attenuated vaccinia virus vector containing genes from the Hantaan virus (nucleocapsid N protein and glycoproteins G1 and G2).
Lead inventor: Connie Schmaljohn, a prominent virologist at the US Army Medical Research Institute of Infectious Diseases (USAMRIID) at Fort Detrick, Maryland.
Assignee: The United States of America as represented by the Secretary of the Army.
US Patent 5,614,193, titled "Hantavirus vaccine," is a 1997 patent for a vaccine designed to induce protective immune responses against hantaviruses in humans.Key Details of US Patent 5,614,193Patent Number: 5,614,193Issue Date: March 25, 1997Filing Date: June 14, 1994 (continuation-in-part of application filed Nov 14, 1991)Assignee: The United States of America as represented by the Secretary of the Army (U.S. Army Medical Research Institute of Infectious Diseases - USAMRIID)Inventors: Schmaljohn; Connie S. (Frederick, MD)Technology: The vaccine uses an attenuated vaccinia virus vector to express hantavirus proteins (specifically M segment proteins) to provide immunity against hantaviruses, such as the Hantaan virus.Background and ContextDevelopment: Developed by the U.S. Army in the early 1990s.Purpose: The invention addresses the need for effective prophylactic agents against Hantavirus Pulmonary Syndrome (HPS) and hemorrhagic fever with renal syndrome (HFRS), which are caused by infections from rodents.Licensing: This patent was listed as available for licensing.Note: There are newer patents related to Hantavirus, such as DNA vaccine patents issued around 2018.
https://patents.google.com/patent/US5614193A/en
US5945277A — Four Corners Hantavirus / Isolated Viral Material
References isolated “Four Corners Virus” hantavirus and genome sequences
https://patents.google.com/patent/US5945277A/en
US5916754A — Bayou Hantavirus
References isolated Bayou hantavirus
https://patents.google.com/patent/US5916754A/en
US20220275346A1 — Hantavirus Antigenic Composition
Modern hantavirus antigen/vaccine platform application
https://patents.google.com/patent/US20220275346A1/en
WO2023043901A1 — mRNA Vaccines Against Hantavirus
International mRNA hantavirus vaccine application
https://patents.google.com/patent/WO2023043901A1/en
SE9600436D0 — Vaccine Against Hantavirus
Swedish hantavirus vaccine patent family
https://patents.google.com/patent/SE9600436D0/en
HU206050B — Process for Producing Hantaan Virus Vaccine
Hantaan virus vaccine production process
https://patents.google.com/patent/HU206050B/en
HUMAN TRANSMISSION / TRANSMISSION RESEARCH
CDC — Person-to-Person Transmission of Andes Virus
https://wwwnc.cdc.gov/eid/article/26/4/19-0799_article
CDC — Andes Virus Outbreak / Human Transmission
https://wwwnc.cdc.gov/eid/article/20/10/14-0353_article
WHO — Hantavirus Fact Sheet
https://www.who.int/news-room/fact-sheets/detail/hantavirus
CDC — Efficient Andes Virus Shedding Study
https://wwwnc.cdc.gov/eid/article/29/10/23-0544_article
MUTATION / REVERSE GENETICS / VIRAL ENGINEERING RESEARCH
Mutations Associated with Human Transmission Characteristics
mSphere / ASM
https://journals.asm.org/doi/10.1128/msphere.00018-23
A Reverse Genetics System for Andes Virus
PubMed Central
https://pmc.ncbi.nlm.nih.gov/articles/PMC3517727/
Rescue of Infectious Hantaan Virus from cDNA Clones
Journal of Virology
https://doi.org/10.1128/JVI.76.14.7074-7082.2002
Generation of Hantavirus-Like Particles Using Recombinant Vaccinia Systems
https://journals.asm.org/doi/10.1128/JVI.73.5.3895-3903.1999
THE HANTAVIRUS VACCINES COULD BE ESPECIALLY DANGEROUS FOR PEOPLE WHO TOOK THE COVID JABS AND SUFFERED DAMAGE TO THEIR IMMUNE SYSTEM
THE US ARMY DEVELOPED A METHOD TO GIVE HANTAVIRUS TO HAMSTERS WHO HAVE DAMAGE TO THEIR IMMUNE SYSTEMS
The hantavirus vaccines are a really worrying element.
A study in the JJournal of Virology from 2014 describes how the hantavirus can infect hamsters if they are immune suppressed, opening the door to a two-step biological weapon—one that suppresses the immune system before introducing a pathogen—to ncrease a disease's lethality. A suppressed immune system significantly lowers the host's ability to fight off infections. Pathogens that are normally treatable or non-lethal can become deadly in immunocompromised populations.Some research suggests that manipulating the human microbiome or immune status could allow pathogens to propagate more efficiently within a population.
Journal of Virology
J Virol. 2014 Jan;88(2):811–819. doi: 10.1128/JVI.02906-13
A Lethal Disease Model for Hantavirus Pulmonary Syndrome in Immunosuppressed Syrian Hamsters Infected with Sin Nombre Virus
Rebecca L Brocato 1, Christopher D Hammerbeck 1, Todd M Bell 1, Jay B Wells 1, Laurie A Queen 1, Jay W Hooper 1,✉
PMCID: PMC3911685 PMID: 24198421
Abstract
Sin Nombre virus (SNV) is a rodent-borne hantavirus that causes hantavirus pulmonary syndrome (HPS) predominantly in North America. SNV infection of immunocompetent hamsters results in an asymptomatic infection; the only lethal disease model for a pathogenic hantavirus is Andes virus (ANDV) infection of Syrian hamsters. Efforts to create a lethal SNV disease model in hamsters by repeatedly passaging virus through the hamster have demonstrated increased dissemination of the virus but no signs of disease. In this study, we demonstrate that immunosuppression of hamsters through the administration of a combination of dexamethasone and cyclophosphamide, followed by infection with SNV, results in a vascular leak syndrome that accurately mimics both HPS disease in humans and ANDV infection of hamsters. Immunosuppressed hamsters infected with SNV have a mean number of days to death of 13 and display clinical signs associated with HPS, including pulmonary edema. Viral antigen was widely detectable throughout the pulmonary endothelium. Histologic analysis of lung sections showed marked inflammation and edema within the alveolar septa of SNV-infected hamsters, results which are similar to what is exhibited by hamsters infected with ANDV. Importantly, SNV-specific neutralizing polyclonal antibody administered 5 days after SNV infection conferred significant protection against disease. This experiment not only demonstrated that the disease was caused by SNV, it also demonstrated the utility of this animal model for testing candidate medical countermeasures. This is the first report of lethal disease caused by SNV in an adult small-animal model.
INTRODUCTION
.....
In the current study, we take an alternative approach to create a model of lethal hantavirus disease by evaluating the pathogenesis of a normally infectious yet nonpathogenic hantavirus in immunocompetent hamsters and in immunocompromised hamsters treated with dexamethasone and cyclophosphamide individually and in combination. This model of SNV-associated lethal disease in Syrian hamsters is the first report of an HPS-like disease caused by SNV in an adult small-animal model and should improve efforts to develop vaccines and therapeutics to prevent and treat hantavirus disease in humans.
.....
Animal models of infectious disease are invaluable tools to study pathogenesis and to discover and test candidate medical countermeasures.
Here, we have used a strategy whereby an immunologically competent animal (i.e., capable of mounting a normal immune response to a vaccine) can be transiently immunosuppressed to allow SNV to disseminate and cause disease that mimics HPS in humans.
https://pmc.ncbi.nlm.nih.gov/articles/PMC3911685/
STUDIES SHOW THE COVID VACCINES DAMAGED IMMUNE SYSTEMS
An suppressed immune system reducing the ability of people to fight off a disease like the hantavirus has been found to be the side effect of covid vaccines.
For example,
Recently, The Lancet published a study on the effectiveness of COVID-19 vaccines and the waning of immunity with time. The study showed that immune function among vaccinated individuals 8 months after the administration of two doses of COVID-19 vaccine was lower than that among the unvaccinated individuals. According to European Medicines Agency recommendations, frequent COVID-19 booster shots could adversely affect the immune response and may not be feasible. The decrease in immunity can be caused by several factors such as N1-methylpseudouridine, the spike protein, lipid nanoparticles, antibody-dependent enhancement, and the original antigenic stimulus. These clinical alterations may explain the association reported between COVID-19 vaccination and shingles. As a safety measure, further booster vaccinations should be discontinued. In addition, the date of vaccination should be recorded in the medical record of patients. Several practical measures to prevent a decrease in immunity have been reported. These include limiting the use of non-steroidal anti-inflammatory drugs, including acetaminophen to maintain deep body temperature, appropriate use of antibiotics, smoking cessation, stress control, and limiting the use of lipid emulsions, including propofol, which may cause perioperative immunosuppression. In conclusion, COVID-19 vaccination is a major risk factor for infections in critically ill patients.
https://pmc.ncbi.nlm.nih.gov/articles/PMC9167431/
Another study on T Cell Exhaustion after the covid vaccine published in 2023 observed that about 30% of patients showed a decrease in interferon-production after a third dose of the covid vacicne, which correlated with higher expression of exhaustion markers like PD-1 and CD57. Another study noted that while vaccination enhanced effector qualities, it also caused an upregulation of inhibitory receptors (PD-1, TIM3) typically associated with exhaustion, though functional quality remained high.
Research on individuals with breakthrough infections found increased expression of the immune checkpoint LAG-3 and impaired booster-induced CD4+ T-cell responses.
A narrative review suggested that frequent mRNA boosters in immunocompromised individuals might lead to impaired activation of CD4+ and CD8+ T cells or high levels of IgG4 antibodies, potentially contributing to immune system "fatigue".
For example
Evidence of exhausted lymphocytes after the third anti-SARS-CoV-2 vaccine dose in cancer patients
Javier David Benitez Fuentes 1,*,†, Kauzar Mohamed Mohamed et al
PMCID: PMC9808030 PMID: 36605446
Abstract
Introduction
Evidence is scant regarding the long-term humoral and cellular responses Q7 triggered by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mRNA vaccines in cancer patients after repeated booster doses. The possibility of T-cell exhaustion following these booster doses in this population has not yet been fully studied and remains uncertain.
Methods
In this single-center prospective observational study, we explored the specific humoral and cellular response to S1 antigen in 36 patients with solid malignancies at baseline, and after the second and third doses of the mRNA-1273 vaccine.
Results
A dual behavior was observed: 24 (66.7%) patients showed partial specific IFN-γ response after the second dose that was further enhanced after the third dose; and 11 (30.5%) already showed an optimal response after the second dose and experienced a marked fall-off of specific IFN-γ production after the third (4 patients negativization), which might suggest T cell exhaustion due to repetitive priming to the same antigen. One (2.8%) patient had persistently negative responses after all three doses. Seroconversion occurred in all patients after the second dose. We then studied circulating exhausted CD8+ T-cells in 4 patients from each of the two response patterns, those with increase and those with decrease in cellular response after the third booster. The patients with decreased cellular response after the booster had a higher expression of PD1+CD8+ and CD57+PD1+CD8+ exhausted T cells compared with those with an increased cellular response both in vivo and in vitro. The proportion of PD1+CD8+ and CD57+PD1+CD8+ exhausted T cells inversely correlated with IFN-γ production.
https://pmc.ncbi.nlm.nih.gov/articles/PMC9808030/
A paper in Food and Chemical Toxicology hypothesized that mRNA vaccines might impair Type I interferon signaling, which is a critical part of the body's innate immune response. The authors suggested this could potentially interfere with the body’s ability to fight other pathogens or surveil for cancer.
...
Food and Chem Toxicol. 2022 Apr 15;164:113008. doi: 10.1016/j.fct.2022.113008
Innate immune suppression by SARS-CoV-2 mRNA vaccinations: The role of G-quadruplexes, exosomes, and MicroRNAs
Stephanie Seneff a,∗, Greg Nigh b, Anthony M Kyriakopoulos c, Peter A McCullough d
Author information
Article notes
Copyright and License information
PMCID: PMC9012513 PMID: 35436552
Abstract
The mRNA SARS-CoV-2 vaccines were brought to market in response to the public health crises of Covid-19. The utilization of mRNA vaccines in the context of infectious disease has no precedent. The many alterations in the vaccine mRNA hide the mRNA from cellular defenses and promote a longer biological half-life and high production of spike protein. However, the immune response to the vaccine is very different from that to a SARS-CoV-2 infection. In this paper, we present evidence that vaccination induces a profound impairment in type I interferon signaling, which has diverse adverse consequences to human health. Immune cells that have taken up the vaccine nanoparticles release into circulation large numbers of exosomes containing spike protein along with critical microRNAs that induce a signaling response in recipient cells at distant sites. We also identify potential profound disturbances in regulatory control of protein synthesis and cancer surveillance. These disturbances potentially have a causal link to neurodegenerative disease, myocarditis, immune thrombocytopenia, Bell's palsy, liver disease, impaired adaptive immunity, impaired DNA damage response and tumorigenesis. We show evidence from the VAERS database supporting our hypothesis. We believe a comprehensive risk/benefit assessment of the mRNA vaccines questions them as positive contributors to public health.
Keywords: SARS-CoV-2 mRNA vaccines, Type I interferon Response, Exosomes, G-quadruplexes, microRNAs, Cancer
https://pmc.ncbi.nlm.nih.gov/articles/PMC9012513/
And this study
Autoimmune Concerns: Rare reports published in PMC have explored associations between vaccination and new-onset autoimmune conditions, where the immune system becomes "dysregulated" and attacks the body's own tissues, though a direct causal link is still being investigated.
mRNA vaccine boosters and impaired immune system response in immune compromised individuals: a narrative review
Alberto Boretti 1,✉
Author information
Article notes
Copyright and License information
PMCID: PMC10821957 PMID: 38280109
Abstract
Over the last 24 months, there has been growing evidence of a correlation between mRNA COVID-19 vaccine boosters and increased prevalence of COVID-19 infection and other pathologies. Recent works have added possible causation to correlation. mRNA vaccine boosters may impair immune system response in immune compromised individuals. Multiple doses of the mRNA COVID-19 vaccines may result in much higher levels of IgG 4 antibodies, or also impaired activation of CD4 + and CD8 + T cells. The opportunity for mRNA vaccine boosters to impair the immune system response needs careful consideration, as this impacts the cost-to-benefit ratio of the boosters’ practice.
https://pmc.ncbi.nlm.nih.gov/articles/PMC10821957/
To sum up, the covid pandemic led to the widespread use of genetic vaccines, including mRNA and viral vector vaccines.
But The Lancet published a study showing that immune function among vaccinated individuals 8 months after the administration of two doses of COVID-19 vaccine was lower than that among unvaccinated individuals. These findings were more pronounced in older adults and individuals with pre-existing conditions.
That means that , theoretically, people who have had the covid jab are more susceptible to getting the hantavirus if a method is used using vaccines for giving hamsters the disease as part of biowarfare.
More on the use of immune systems for biowarfare at
National Academies of Sciences, Engineering, and Medicine; Division on Earth and Life Studies; Board on Life Sciences; Board on Chemical Sciences and Technology; Committee on Strategies for Identifying and Addressing Potential Biodefense Vulnerabilities Posed by Synthetic Biology.
Washington (DC): National Academies Press (US); 2018 Jun 19.
Biodefense in the Age of Synthetic Biology.
Show details
6Assessment of Concerns Related to Bioweapons that Alter the Human Host
While we typically think about biodefense in terms of either pathogens (Chapter 4) or biochemicals (Chapter 5), technological advances are now making possible additional capabilities and means of attack that are more closely related to the human body itself. The study included consideration of how increased knowledge about the microbiome and immune system may enable new means of delivering an agent; the potential for incursions into the human host through means not typical of pathogens or toxin-based bioweapons, such as through genetic modification; and how genes themselves may potentially be used as weapons. While some of these potential activities overlap with the activities discussed in previous chapters, it is valuable to consider them from a host-centric angle to assess how advances in knowledge and biotechnology tools might further alter the landscape of vulnerabilities and weapons available for exploitation by malicious actors.
https://www.ncbi.nlm.nih.gov/books/NBK535870/
MODIFYING THE HUMAN IMMUNE SYSTEM
Human immunity is the bulwark for protection against infectious disease. Two basic systems respond to the vast array of threats in the natural environment. The first is the innate immune system, a collection of nonspecific protective mechanisms triggered by pathogen-associated molecular patterns, such as lipoteichoic acid from Gram-positive bacteria or unmethylated CpG sequences in viral DNA. The second is the adaptive immune system, which generates highly specific antibody and T-cell responses tailored to individual diseases and disease variants. Many natural pathogens manipulate the human immune system, both by suppressing the immune response (e.g., immunodeficiency viruses) and by upregulating certain responses (e.g., respiratory syncytial virus, which induces the immune system to favor a response involving Type 2 T helper cells [Th2] and subsequently increases the proclivity toward asthma [Lotz and Peebles, 2012]). These examples suggest that it may be feasible to develop a bioweapon capable of manipulating or “engineering” the immune response. Several potential forms for such a bioweapon were considered:
Engineering immunodeficiency. Manipulating a target population to have decreased immunity could increase the impact of a biological attack. This goal could be pursued either by manipulating a pathogen to simultaneously reduce immunity and cause disease (Jackson et al., 2001) or by separately introducing an immune-suppressing agent and a bioweapon into a target population. Agents used to cause immunodeficiency could be pathogens (e.g., the insidious spread of HIV [human immunodeficiency virus]) or chemicals (see NRC [1992] and IPCS [1996] for discussions of chemicals that contribute to immunotoxicity). It is also possible that a disease agent could be tailored to the immune state of a population, either by engineering the agent to avoid extant adaptive or innate immune barriers or by actually taking advantage of those barriers (for further discussion see Chapter 7, Health-Associated Data and Bioinformatics).
....
Engineering autoimmunity. Natural autoimmune diseases cause significant disability and death. It may be possible to engineer a disease that causes the body to turn on itself. Mouse models for the stimulation of autoimmunity now exist. For example, Experimental Autoimmune Encephalomyelitis, which mimics the symptoms of the human malady multiple sclerosis, has been induced in mice by immunization with antigens that cause an immune response (autoantigens; see Miller et al., 2007). Normally, such self-immunization is prevented by the mechanisms that ensure exclusion of antibodies and T-cells that are self-reactive, but some pathogens may present antigens that are similar enough to the body's own proteins that the original immune response spreads from the pathogen to the new human target. Research into checkpoint inhibitors, compounds designed to unleash the human immune system to eradicate tumors, could also potentially inform efforts to purposely engineer autoimmunity. By overstimulating the immune system, checkpoint inhibitors have been shown to lead to autoimmunity, often in the form of colitis (June et al., 2017). In addition, particular compounds have been shown to lead to an autoimmune disease of the liver (Tanaka et al., 2017, 2018). One potential route of attack could be to introduce such compounds via the microbiome.
CONCLUSION
A FAMILIAR SCHEME BUT ONE NO LONGER ACCEPTED BY THE PUBLIC
As Katherine Wallace wrote in Statnews what I am writing is now the d facto accepted mainstream narrative.
From media
Former Rep. Marjorie Taylor Greene amplified the framing, writing that pharmaceutical companies “manipulate the virus, make the vaccine, and then make the profits.”
....
During Covid, this process sometimes took weeks to fully build momentum. Now it happens within hours. This time I saw scientists on social media joking about imminent conspiracy claims before the first major misinformation posts had even appeared. We all know the script.
...
People were reposting a social media prediction from 2022 that said: “Corona ended, 2026: Hantavirus.” It was being framed as evidence that the outbreak had been planned years in advance.
...
Each cycle conditions more people to approach infectious disease stories through the same preloaded assumptions: The cure is being hidden, the government is lying, scientists are corrupt, vaccines are the real threat.
And increasingly, those messages are not coming from fringe corners of the internet.
Pew Research Center data published this week found that half of Americans under 50 get health and wellness information from influencers and podcasts. Many of the people shaping those conversations present themselves as medical experts despite having little or no relevant expertise.
That audience is enormous. And it’s growing.
So, when a future outbreak with real pandemic potential eventually emerges, and one will, millions of people will encounter it inside an information environment already primed to distrust public health guidance before it even arrives. The narratives are prewritten now. The audience already knows the cues.
What worries me most is not that misinformation exists. It’s that we’ve started treating this environment as normal.
https://www.statnews.com/2026/05/08/hantavirus-outbreak-misinformation-spreads-faster-than-virus/
And this should worry you too at WHO and at Moderna.
Investors in Moderna s stock are anticipating a mass vaccination campaign ordered by WHO for how else to explain the massive amount of money pouring into the company, which just so happened to have a hantavirus virus in preclinical production after collaboraring with the US army as discussed.
Are you planning to authorize this vaccine under so called emergency use regulations like the covid jab to hide the harms?
A study published in The Journal of Infectious Diseases on Safety and Immunogenicity of an Andes Virus DNA Vaccine by Needle-Free Injection: A Randomized, Controlled Phase 1 Study found a 98% of the people had an adverse event
https://pmc.ncbi.nlm.nih.gov/articles/PMC10786244/
And why needle free injections? Are people not to know they are going to be given the vaccine material because it is not injected using a needle?
Finally, I urge you and WHO as well as the Prime Ministers of Spain and Greece,who are ccd in on emails, to take legal advance because in 2026 the public will not accept a repeat of covid, not accept lockdowns, mass vaccination campaigns with experimental jabs for the profit of pharmaceutical companies and for political gain, and yet, you have , apparently, set just such a scheme in motion.
The same applies, of course, to Bill Gates, prime suspect in 15 218, whose Foundation ran WHO s covid response according to an investigation by Politico and die Welt and who be the prime suspect behind your ill considered measures for the hantavirus.
https://www.politico.com/news/2022/09/14/global-covid-pandemic-response-bill-gates-partners-00053969
Indeed, I encourage authorities around the world to use the prosecutor probes D 15 218 and E 17 449 to prove definitively that covid was a scheme and to investigate the hantavirus as a scheme and hold those responsible to account on the bass of the law.
Please do not hesitate to contact me if you have any questions.
Respectfully,
Jane Burgermeister
No comments:
Post a Comment